Shan-Siddiqi, neuropsychiatrist, Harvard
Dr. Shan Siddiqi, MD

Dr. Siddiqi completed his residency at Washington University in St. Louis, a leading institute in functional brain imaging, where he collaborated with other imaging experts to develop novel methods for targeting TMS treatments. The group used functional MRI (fMRI) scans to create patient-specific maps of brain system architecture, which revealed significant variability between patients. This discovery is particularly important in treating patients with brain injury, who often have multiple disruptions in their brain architecture. The method proved to be extremely effective in a pilot placebo-controlled study of patients with TBI-associated depression. As a result, this preliminary work is now being scaled up for a larger multi-center study with the military.

After his work in St. Louis, Dr. Siddiqi moved on to Harvard Medical School to learn from experts in TMS and fMRI. Currently he works with world leaders in TMS at the Berenson-Allen Center for Noninvasive Brain Stimulation, further developing methods for individualizing TMS treatments.

Dr. Siddiqi’s innovations, many of which have patents and publications pending, led to the development of a startup company, SigNeuro LLC. Dr. Siddiqi learned about Kaizen Brain Center at the 2017 Clinical TMS Society conference and selected Kaizen as the best place to begin implementing the company’s technologies. SigNeuro now provides Kaizen with early access to their latest developments in personalizing TMS therapy, and Dr. Siddiqi consults with Kaizen specialists to plan treatment approaches based on an individual’s unique clinical history, symptom profile, and advanced functional brain imaging.

Peer-reviewed Articles

Siddiqi SH, Creech ML, Black KJ. Orthostatic stability with intravenous levodopa. 2015, 3:e1198.
Siddiqi SH, Trapp NT. Transcranial direct current stimulation: theory, use for major depressive disorder, and other neuropsychiatric applications. Am J Psych Residents’ Journal, October 2015.
Siddiqi SH, Black KJ, Womer FY. Impact of a structured review session on medical student psychiatry subject examination scores. F1000Research 2015, 4:897.
Siddiqi SH, Geiger CL, Abraham NK, Karimi M, Perlmutter JS, Black KJ. The human experience with intravenous levodopa. Frontiers in Pharmacology 2016, 6:307.
Siddiqi SH, Chockalingam R, Cloninger CR, Lenze EJ, Cristancho P. Use of the Temperament and Character Inventory to predict response to repetitive transcranial magnetic stimulation for major depression. Journal of Psychiatric Practice, 2016;22(3):193-202.
Cristancho P, Trapp NT, Siddiqi SH, Dixon D, Miller JP, Lenze EJ. Crossover to Bilateral Repetitive Transcranial Magnetic Stimulation: A Potential Strategy When Patients Are Not Responding to Unilateral Left-Sided High-Frequency Repetitive Transcranial Magnetic Stimulation.J ECT, 2018; ePub ahead of print.
Siddiqi SH, Trapp NT, Hacker CD, Laumann TO, Kandala S, Hong X, Trillo LT, Shahim P, Leuthardt EC, Carter AC, Brody DL. Repetitive Transcranial Magnetic Stimulation with Resting State Network Targeting for Treatment-Resistant Depression in Traumatic Brain Injury: a randomized, controlled, double blinded pilot study. J Neurotrauma. 2018; ePub ahead of print.
Siddiqi SH, Trapp NT, Shahim P, Hacker CD, Laumann TO, Kandala S, Carter AC, Brody DL. fMRI-targeted rTMS for neuropsychiatric sequelae of repetitive traumatic brain injury in a retired NFL player. In press at J Neuropsych Clin Neurosci.
Siddiqi SH,Taylor SF, Cooke DC, Pascual-Leone A, George MS, Fox MD. Distinct symptom-specific targets for circuit-based neuromodulation. Submitted to Nat Med.

Poster Presentations

Phillips J, Siddiqi S, Burnett J, Banning M, Meyers N, Rogers J, Kraatz J. Diagnosis, monitoring, and treatment of Ventilator-Associated Pneumonia using the LungGuardian system. Presented at Missouri Life Sciences Week, April 2007.
Phillips J, Burnett J, Siddiqi S, Bothwell M. Pediatric patients have shorter lansoprazole half-life than previously reported. American Journal of Gastroenterology abstracts, September 2007 supplement. Presented at American College of Gastroenterology annual meeting, October 2007.
Phillips J, Bothwell M, Ramachandran V, Siddiqi S, Balkin E. Successful use of wireless pH monitoring in infants.Presented at American Pediatric Surgical Association annual meeting, May 2008.
Siddiqi SH, Chockalingam R, Cloninger CR, Lenze EJ, Cristancho P. Persistent temperament score predicts response to repetitive transcranial magnetic stimulation (rTMS) for major depression. Presented at International Society for ECT and Neurostimulation, May 2015. Archived Poster .
Siddiqi SH, Cloninger CR, Cristancho P. Temperament and cortical excitability: associations with novelty seeking and persistence. Presented at the American Neuropsychiatric Association, March 2016. Manuscript in preparation.
Siddiqi SH, Trapp NT, Hacker CD, Laumann TO, Kandala S, Hong X, Carter AC, Brody DL. Individualized Connectome Mapping to Target rTMS for Depression in TBI. Presented at the American Neuropsychiatric Association (both oral and poster), March 2017; study ongoing.
Siddiqi SH, Eisenstein S, Koller JM, Hershey T, Black KJ. 3D Statistical Mapping of Acute Psychiatric Effects of Various DBS Stimulation Sites in Parkinson Disease. Presented at the American Neuropsychiatric Association, March 2017.
Siddiqi SH, Trapp NT, Shahim P, Hacker CD, Laumann TO, Kandala S, Carter AC, Brody DL. fMRI-targeted rTMS for neuropsychiatric sequelae of repetitive traumatic brain injury in a retired NFL player. Presented at Clinical TMS Society annual meeting, May 2017.
Siddiqi SH, Hacker CD, Kandala S, Laumann TO, Trapp NT, Brody DL, Carter AC. “Individualized precision targeting of resting-state networks.” Presented at International Society for ECT and Neurostimulation, May 2017. Manuscript in preparation.
Siddiqi SH, Weigand A, Pascual-Leone A, Fox MD. “Individualized connectivity between rTMS targets and the subgenual cingulate is unrelated to antidepressant response” Presented at European Conference on Brain Stimulation and Psychiatry, October 2017. Manuscript in preparation.
Siddiqi SH, Trillo LT, Trapp NT, Hacker CD, Laumann TO, Carter AR, Brody DL. “Individualized modeling of large scale functional network dynamics with fMRI and rTMS” To be presented at American College of Neuropsychopharmacology, December 2017.

Oral Presentations

“rTMS with individualized resting-state network mapping for depression in TBI” – American Neuropsychiatric Association, March 2017
“Precision medicine in neuromodulation” – Washington University Psychiatry Grand Rounds, April 2017
“Modulation and modeling of mind-brain systems” – Washington University Psychiatry Grand Rounds, May 2017
“Individualized precision targeting of resting-state networks with transcranial magnetic stimulation” – Computational Psychiatry satellite meeting for Society of Biological Psychiatry, May 2017
“Targeted stimulation of brain networks in TBI-associated depression” – Military Health Services Research Symposium, August 2017

Educational Lectures

End-of-clerkship psychiatry shelf review course, monthly during academic years 2014-15 and 2015-16
“Introduction to neuroimaging” lecture for PGY3/4 psychiatry residents, March 2017 and Jan 2018
“Introduction to brain networks” lecture for PGY3/4 psychiatry residents, April 2017 and Feb 2018

I am so grateful for the entire team at Kaizen. My son has a TBI and we have never received such stellar treatment. Dr. Ahmed has put together a team of professionals like no other. Thank you for all you have done and continue to do for my family!

Lisa
Traumatic Brain Injury Patient’s Parent

Now accepting TRICARE. To all who have served and continue to serve our country, we thank you.